Clinical Research of Gimeracil Capsule Combined with Zhen Stilbene Righting Capsules in Treatment of Senile Non-small Cell Lung Cancer

LIU Jing; ZHAO Zeng-hu; YANG Wen

doi:10.3969/j.issn.1002-3429.2015.06.027

Abstract：Objective To discuss the clinical effect of Gimeracil Capsule combined with Zhen Stilbene Righting cap-sules in treatment of senile patients with non-small cell lung cancer. Methods 66 non-small cell lung cancer patients ( 75 years old and over) were randomly divided into observation group (32 cases) and control group(34 cases). Observation group received Gimeracil capsules combined with Zhen Stilbene Righting capsules,Gimeracil capsules 40-60 mg / each time, two times per day for 14 days and then rested for 7 days. 6 Zhen Stilbene Righting capsules were given each time, two times per day. Control group received Eliminate cancer Flat capsules combined with Zhen Stilbene Righting capsules, Eliminate cancer flat capsules ( 4-5 grains/each time), three times per day, Zhen Stilbene Righting capsules, (6 grains/each time), two times per day. Three weeks was a cycle, and there were 6 cycles and the curative effect was reviewed. The medication contin-ued until the patient was not able to tolerate and then it was stopped. A follow-up was carried out till the patients died. Re-sults Statistically significant difference between the two groups was observed with the disease control rates ( DCR ) ( P <0. 01). The rate of the observation group was 75. 0%, whereas that of the control group was 11. 8%. The time to progression (TTP), the overall survival(OS)and the 1-year survival rate of the observation group were (3. 42 ± 1. 21) months,(13. 94 ± 2. 53)months and 34. 4% respectively, whereas that in the control group were (0. 83 ± 0. 42) months,(7. 62 ± 1. 35) months and 8. 8%. Statistically significant difference was observed between the two groups(P<0. 05). But there was no statistically significant difference between the blood toxicity reaction and gastrointestinal toxicity reaction of the two groups ( P>0. 05 ) . Conclusion Gimeracil Capsule combined with Zhen Stilbene Righting Capsules is safe and effective in the treatment of senile non-small cell lung cancer.