Comparison of the Effect of Magnesium Sulfate Used with Different Administration Route in Asthmatic Bronchitis in Infants

ZHU Yan; QI Ge-yao; ZHONG Jia-wei

doi:10.3969/j.issn.1002-3429.2015.06.026

Abstract：Objective To observe the clinical effect of magnesium sulfate used with different administration route in infants with asthmatic bronchitis. Methods:160 infants with asthmatic bronchitis were selected and divided randomly into 4 groups (n=40) according to therapy;control group, experimental group Ⅰ, experimental group Ⅱ and experimental groupⅢ. Methods Infants in the control group were given the conventional treatment with anti-virus medication and spasmolysis, and infants in each experimental group were given other therapeutic schedules on the basis of control group. Infants in the ex-perimental groupⅠwere administered with inhaled MgSO4 on the basis of conventional treatment;Infants in the experimental group Ⅱ were given intravenous MgSO4 on the basis of conventional treatment;infants in the experimental groupⅢwere given the inhaled salbutamol combined with budesonide on the basis of conventional treatment. The clinical effect in the four groups and adverse reactions in two groups with MgSO4 were compared. Results The time of experimental groups in each observation index was shorter than that of control group, and the differences were significant(P<0. 05). The differences of time in each observation index, however, were not significant(P>0. 05)between any of the two groups and the experimental groups. The rate of adverse reactions in experimental group Ⅰ was 7. 5%(3/40) but the rate in experimental group Ⅱ was 25. 0%(10/40). The difference of adverse reaction in the two groups showed significant difference(P<0. 05). Conclusion MgSO4 in treatment of infant asthmatic bronchitis based on conventional therapy can improve the therapeutic effect and shorten the thera-peutic time. Moreover, inhaled MgSO4 is safer than intravenous style.