Relationship between Performance State Score and Acute Radiation Toxicity, Short-term Efficacy in Patients with Head and Neck Cancer
ZHAO Zi-wei
ZENG Yue-can
WU Rong
WU Li-na
ZHANG Zhen-yong
HU Tian-yu
Abstract：Objective To analyze the performance state ( PS) score of patients with the head and neck cancer and its relationship with acute radiation toxicity and short-term efficacy. Methods 37 patients with head and neck tumors underwent radical radiotherapy for the first time in our hospital and Zubrod-ECOG-WHO ( ZPS, 5 scores method) score standard was used to evaluate PS scores before radiotherapy. We evaluated recent effects of radiotherapy one month after treatment respec-tively. Logistic regression for the analysis of relationship among PS scores before radiotherapy of patients was used to evaluate the dose of radiation and acute radiation toxicity simultaneously and to analyze the correlation between PS score before radio-therapy and recent efficacy. Results Logistic regression analysis showed that PS score before radiotherapy and radiation dose were significantly correlated with mouth drying, radiodermatitis, mucositis, dysgeusia, pharyngitis or sore throat, fatigue and swallowing difficulty. The difference was statistically significant (P=0. 001 or P<0. 001). Radiation dose was positively cor-related with anorexia and the difference was significant (P<0. 001). We recorded 32. 43% of complete remission after one month of radiotherapy, partial remission accounted for 37. 84%, 21. 62%, which was in a stable stage and 8. 11% was in progress. Logistic regression analysis showed a significant correlation between PS score before radiotherapy and recent efficacy after radiotherapy. The difference was statistically significant (P<0. 001). Conclusion High scores of PS scores before ra-diotherapy in patients with head and neck cancer and large dose of radiation therapy may lead to severe acute radiation toxcity, and high scores of PS scores before radiotherapy may lead to poor short-term efficacy.
Keywords：Head and neck neoplasmPerformance state scoreRadiation injuryTreatment outcome
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 100-103 )