Misdiagnosis Analysis and Therapeutic Summary of Heroin Associated Nephropathy
CHEN Yan
ZHU Xiao-lei
ZHU Wei-wei
WANG Yue-juan
SUN Wei
Abstract：Objective To explore the clinic features and treatment of heroin associated nephropathy ( HAN) in order to reduce the rates of missed diagnosis and misdiagnosis. Methods The clinical data of one case with HAN, who was misdi-agnosed as having nephrotic syndrome, were retrospectively analyzed. Results A male patient had been admitted to another hospital for generalized edema and dropsy of serous cavity, and laboratory analysis revealed nephrotic proteinuria, hypo-albu-minemia, and hyperlipidemia. The patient was diagnosed as having nephritic syndrome. After symptomatic therapy, edema subsided. The patient was admitted to our hospital for a relapse of oliguria and edema for 10 days. The patient had a history of heroin abuse and chronic hepatitis C virus infection for more than 10 years. Pathological findings of the renal biopsy demon-strated Focal Segmental Glomerulosclerosis ( FSGS ) , and negative staining for immunoglobulin and C3 in immunofluores-cence. The possibility of secondary glomerular disease was excluded;the patient was diagnosed as having HAN. After the use of heroin was discontinued and treatment with antiviral agents and Glucocorticoids was applied, clinical status of the patient was improved. Conclusion Nephrotic syndrome is the main clinical manifestation of HAN, and the predominant pathologic lesion is FSGS. Combined therapy including discontinuation of the use of heroin as early as possible, and treatment with Glu-cocorticoids, and antiviral agents for hepatitis may improve the prognosis.
Keywords：Heroin associated nephropathyMisdiagnosisNephrotic syndromeTreatment
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 35-38 )