Observation of Anaesthetic Effect of Small Dose of Dexmedetomidine Combined with Propofol during Painless Colonoscopy

JIA Xu; GU Jia; HAN Tao; LIU Zhao-zhe; PEI Ling

doi:10.3969/j.issn.1002-3429.2015.04.032

Abstract：Objective This clinical study was conducted to investigate the anesthetic effect and safety of small dose of dexmedetomidine ( DEX) combined with propofol in patients undergoing painless colonoscopy. Methods A total of 110 patients undergoing painless colonoscopy during June 2013 to February 2014 in our hospital were selected. The patients were randomly di-vided into DEX combined with propofol (observation group, n=55) and sufentanil combined with propofol (control group, n=55). The patients in observation group were given DEX 0. 5 μg/kg (diluted to 10 ml) combined with 1-1. 5 mg/kg propofol, while the patients in the control group were given sufentanil 0. 5μg/kg (diluted to 10 ml) combined with 1-1. 5 mg/kg propofol. In some patients, additional doses of propofol (0. 2-0. 5 mg/kg) were given according to the body activity and operation time. The consumed dose of propofol, operation time, full recovery time, visual analog scale ( VAS) 30 min after operation, and ad-verse reactions were recorded. Mean arterial pressure ( MAP ) , heart rate ( HR ) , and hemoglobin oxygen saturation levels ( SpO2 ) at the time before check ( T0 ) , 5 min after propofol ( T1 ) , splenic flexure ( T2 ) , hepatic flexure ( T3 ) , and at the end (T4) were recorded. Results The total amount of propofol in observation group (110. 5 ± 15. 7) was significantly lower than that in the control group (150. 3 ± 19. 5). The operation time, full recovery time and VAS were similar in both groups. Com-pared with the control group, MAP and SpO2 were significantly increased at T1- T3(P<0. 05), HR decreased significantly at T1-T4(P<0. 05) in the observation group. The respiratory depression, hypotension, poor body movement, and intestinal angina in the observation group were significantly lower than that in the control group (P<0. 05 or P<0. 01). Conclusion The anes-thetic effect of small dose of DEX combined with propofol on patient undergoing painless colonoscopy is significantly better than that of sufentanil combined with propofol. The small dose of DEX combined with propofol can reduce the occurrence of the ad-verse reaction, reduced the dose of propofol, and avoid respiratory depression. Small dose of DEX combined with propofol is a safe and an effective anesthetic method for patients undergoing painless colonoscopy.