Misdiagnosis Analysis of Anti-NMDAR Encephalitis
LI Ying
XIA Zhen-xi
LIU Nan
DING Ji-zhao
HUANG Yong-hua
Abstract：Objective To improve awareness of N-methyl-D-aspartate receptor encephalitis and prevent misdiagnosis. Methods The misdiagnosis cause was retrospective analyzed for 3 cases in our department and related literature was re-viewed. Results In 3 cases, 2 cases showed seizure and 1 case showed behavioral abnormalities at onset. 2 cases were misdi-agnosed as viral encephalitis and 1 case was misdiagnosed as brain glioma on admission. The virus testing in cerebrospinal flu-id ( CSF) and the serum tumor maker were normal. Autoimmune encephalitis was considered based on different clinical symp-toms. Lumber puncture was performed and anti-NMDAR antibody was positive in CSF. Anti-NMDAR encephalitis was con-firmed. The patients were treated with glucocorticoids and/or immune globulin and recovered with mild memory loss and/or dull reaction. Conclusion Anti-NMDAR encephalitis should be considered if the patients show seizure or psychological symp-toms with movement disorders and autonomic dysfunction. To test anti-NMDAR antibody in CSF and/or in serum is necessary in diagnosis of the disease.
Keywords：N-MethylaspartateAnti-N-Methyl-D-Aspartate receptor encephalitisMisdiagnosisEncephalitisvi-ralBrainneoplasm
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 33-37 )