Influence of the Effect of Umbilical Cord Derived Mesenchymal Stem Cells on Non-Identical Heterogenic Peripheral Hematopoietic Stem Cells Transplantation
WANG You-jun
LI Dong-liang
Abstract：Objective To investigate the effect of peripheral blood hematopoietic stem cell transplantation ( allo-HSCT)combined with umbilical cord blood mesenchymal stem cell(UCMSC) infusion in treatment of severe aplastic anemia (SAA). Methods 14 patients undergoing haploidentical allo-HSCT in Hematology Department of Bethune International Peace Hospital during July 2007 and June 2013 were divided into two groups according to application of UCMSCs. 7 patients underwent haploidentical allo-HSCT combined MSC infusion. , Other patients underwent haploidentical allo-HSCT only,and hematologic recovery, GVHD related syndrome and complications after the transplantation were observed. Results All the 14 patients achieved hematopoietic reconstitution , the average time of neutrophil and platelet engraftment in the patients undergo-ing haploidentical allo-HSCT combined MSC infusion were 17 (14-21)d and 19 (18-22)d respectively, 21(19-25)d and 21 (20-26)d after haploidentical allo-HSCT. There were significant differences between the two groups ( F = 10. 556, P =0. 007, F = 6. 644, P = 0. 024). The rates of aGVHD and cGVHD were 29% and 43% respectively in the former, 43% and 71% in the latter. 14 pretreated patients did not develop significant liver or kidney damages, hepatic veno-occlusive disease occurred only in one case, which improved after treatment. The median follow-up time was 14. 5 ( 6 to 74 ) months in all the patients. 12 Patients were all alive in disease-free state. 2 patients undergoing haploidentical allo-HSCT developed GVHD and died of sever infection caused by immunosuppressor. Conclusion The haploidentical all-HSCT combined with UCMSCs infu-sion in treatment of SAA can significantly improve the efficacy of treatment and reduce the incidence rate of GVHD and mortal-ity rate.
Keywords：Anemiaaplasticnon-identical hematopoietic stem cells transplantationumbilical cord derive mesen-chymal stem cellTreatment outcomeGraft versus host disease
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 85-89 )