Effect Evaluation of Different Dosages of Dezocine in Prevention of Adverse Reactions During Postoperative General Anesthesia Revival Period after Nasal Surgery

Zhao Yong-jun

doi:10.3969/j.issn.1002-3429.2015.02.037

Abstract：Objective To observe the effects of different dosages of Dezocine in prevention of adverse reactions dur-ing postoperative general anesthesia revival period after nasal surgery. Methods A total of 60 patients undergoing nasal sur-gery under general anesthesia from Remifentanil and Sevoflurane were selected from our hospital during January to December 2013 and were divided randomly into 3 groups (0. 10, 0. 15, and 0. 20 mg/kg Dezocine groups), with 20 patients in each group. 15 minutes before the end of surgery, intravenous Dezocine was injected to the three groups in the units of 0. 10, 0. 15, 0. 20 mg/kg respectively. Recovery time of spontaneous breathing, eye opening time, extubation time, before anesthesia (T0), before extubation (T1), extubation (T2), 10 min after extubation (T3), 30 min after extubation(T4), 60 min after extubation (T5), mean arterial pressure after extubation (MAP), heart rate (HR), pulse oximetry (SpO2) were observed. Cough score was recorded at extubation time, and SAS, VAS for agitation and pains were observed 5 min after extubation. Re-sults The eye opening time and extubation time were elongated gradually as the increase concentration of Dezocine in the 3 groups but the SAS score decreased with increasing concentration along with the concentration increase of Dezocine. The differ-ences between the 3 groups were statistically significant ( P<0. 05 ) . Cough score was decreased sequentially along with the concentration increase of Dezocine in the 3 groups, and 0. 20 mg/kg Dezocine group was compared with 0. 10, 0. 15 mg/kg Dezocine group with significant difference (P<0. 05). The VAS was reduced sequentially along with increasing concentration of Dezocine in the 3 group, and 0. 15, 0. 20 mg/kg Dezocine group was compared with 0. 10 mg/kg Dezocine group with sig-nificant difference (P<0. 05). MAP in the three groups was higher in T1, T2 and T3 than that in T0. MAP gradually de-creased in T1, T2, T3 along with the increasing concentration of Dezocine, and the difference was statistically significant (P<0. 05). The HR in the three groups was higher in T1, T2 than that in T0, and the difference was statistically significant (P<0. 05). HR gradually decreased in T1, T2 along with the increasing concentration of Dezocine, and 0. 20 mg/kg Dezo-cine group was compared with 0. 10, 0. 15 mg/kg Dezocine group with significant difference (P <0. 05). SpO2 in the 3 groups did not show difference of statistical significance (P>0. 05). Conclusion In nasal surgery under general anesthesia from Remifentanil and Sevoflurane, intravenous Dezocine in the unit of 0. 15 mg/kg can effectively reduce pain, cardiovascular stress reaction, extubation cough and agitation 15 minutes before the end of surgery.