Expression and Significance of GATA-3 and T-bet in Both Placenta and Serum of Patients with Hypertensive Disor-der during Pregnancy
YU Jin
YE Sheng-quan
YAN Da-jing
SUN Zhe
YANG Ya-jun
ZHANG Ming-liang
YANG Cheng-lin
Tai-He
Abstract：Objective To observe the expression of GATA-3 and T-bet in both placenta and blood serum of patients with hypertensive disorder during pregnancy and to investigate the relationship between the GATA-3, T-bet and the hyperten-sive disorder during pregnancy. Methods A total of 47 patients who suffered from preeclampsia or eclampsia disorder during pregnancy were divided into three groups: gestational hypertension group (11 patients), severe preeclampsia group (18 pa-tients) and eclampsia group (18 patients). 20 normal pregnant women were chosen as normal pregnancy group. Immunohisto-chemistry and ELISA were used to examine the placenta and blood serum expression of GATA-3 and T-bet. Results GATA-3 and T-bet were expressed in placenta and serum of patients with hypertensive disorders during pregnancy and normal preg-nancy. The levels of GATA-3 in the placenta and serum were the highest and T-bet was the lowest in normal pregnancy group, and differences between the normal pregnancy group and hypertensive disorders group were significant (P<0. 01). Placenta and blood serum of GATA-3 in the 3 groups of gestational hypertension patients decreased as the condition deteriorated, but T-bet concentration increased as the condition deteriorated, and the differences among the three groups showed significant differ-ence (P<0. 01). Conclusion The expressions of GATA-3, T-bet in placenta and blood serum are closely related to hyper-tensive disorders during pregnancy and degree of severity.
Keywords：Hypertensionpregnancy-inducedT-betGATA-3
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 94-97 )