A Meta-analysis of the Combination of Transarterial Chemoembolization and Percutaneous Radiofrequency Ablation for Treatment of Primary Liver Cancer
HU Yi
XU Xi-ming
Abstract：Objective To review the effectiveness of the combination of transarterial chemoembolization ( TACE) and percutaneous radiofrequency ablation (PRFA) for treatment of hepatocellular carcinoma. Methods The documents of ran-domized controlled trials ( RCT) related to the combination of TACE and PRFA for treatment of primary liver cancer from the establishment time of the data-bases to March 2014 were retrieved from the databases of CNKI, CBM, VIP, PubMed, Co-chrane, EMbase and there ferrous in RCT were retrieved by hand at the same time. The documents were screened, extracted and evaluated according to in-collusion and exclusion criteria, and then went through a meta-analysis. Results There were totally 10 RCT (798 patients included). The results of meta-analysis showed as follows:the 3-year overall survival rate, inac-tivation rate of tumors, recurrence of the combination of TACE and PRFA were much better than that of TACE [ OR=2. 72, 95% CI (1. 81, 4. 10), P<0. 01;OR=3. 74, 95% CI (2. 25, 6. 23), P<0. 01; OR=0. 38, 95% CI (0. 24, 0. 61), P<0. 01]. There were significant statistical differences in the complete necrosis rates of tumors, but there were no significant statistical differences in the attenuation rates of positive AFP [OR=1. 40, 95% CI (0. 65, 3. 01), P=0. 39]. Conclusion The combination of TACE and PRFA has more advantages in terms of safety and efficacy in the treatment of HCC than that of TACE monotherapy, but further research is needed.
Keywords：Liver neoplasmaHepatic arteryEmbolizationtherapeuticCatheter ablationMeta-analysis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 101-105 )