Drug Hypersensitivity Syndrome Caused by Allopurinol:A Report of 3 Cases and Literature Review
CHEN Yana
ZHU Xiao-leia
SHENG Mei-xiaoa
ZHAO Jian-xueb
Abstract：Objective To explore the clinical features and treatment of drug hypersensitivity syndrome ( drug rash with eosinophilia and systemic symptoms, DRESS) caused by allopurinol. Methods Clinical data of 3 patients with DRESS caused by allopurinol admitted to our hospital in recent years were retrospectively analyzed. Results Three patients com-plained of fever, generalized rash, impaired renal and hepatic function and hematologic abnormalities after 1-2 weeks of allo-purinol treatment for gout or hyperuricemia. Two patients developed oliguria, and the other one developed cholestasis icterus. Three patients were all diagnosed as having allopurinol allergy, DRESS, and were all treated with glucocorticosteroid or com-bined with intravenous immunoglobulin. Two patients had dramatic improvement in clinical condition, but relapsed as glu-cocorticosteroid tapered off. One of the patients died and one gave up further therapy after his condition deteriorated. Conclu-sion The clinical presentation of drug hypersensitivity syndrome caused by allopurinol is diverse. High-dose glucocorticoste-roid administered early can provide dramatic improvement in clinical condition, but relapse occurs when prednisone is tapered. So a slow taper off of glucocorticosteroid is required upon remission.
Keywords：AllopurinolDrug hypersensitivity syndromeDrug rashDrug toxicityMisdiagnosis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 76-79 )