Pathogens and Antibiotic Resistance of Bloodstream Infections in Pinggu County Area

ZHAO Ming-ze; LI Yan; LIU Lian-qing; WANG Rui-jing; CHEN Hua-wei; ZHANG Wen-jun

doi:10.3969/j.issn.1002-3429.2014.12.036

Abstract：Objective To investigate the cause of clinical bloodstream infection (bloodstream infections, BSI) in pa-tients with pathogenesis, pathogenic species and drug resistance characteristics in Pinggu Area. Methods Blood culture, iden-tification of isolates, and antibiotics sensitivity test of suspected BSI patients were performed. Results In this study, blood cul-ture was positive in 453 patients (12. 84%), which had underlying diseases in 397 cases, 28 cases had duplicated strains in the same patient, but did not have underlying diseases. 281 strains of gram negative bacteria (62. 03%) and 172 strains of gram positive bacteria (37. 97%) were isolated. The detection rate of top 5 pathogens were Escherichia coli (26. 49%), Staphylococ-cus hominis (8. 39%), Acinetobacter baumannii (8. 17%), Staphylococcus epidermidis (7. 28%) and Enterobacter cloace (4. 86%). The main gram negative bacteria, Enterobacter cloacae to ampicillin were resistant and resistance rate to cefuroxime rate was more than 50%. Escherichia coli to ampicillin resistance rate was 84. 17%, sulfamethoxazole resistance rate was 71. 67%, and resistance rate to cefuroxime was more than 50%. Acinetobacter baumannii was sensitive to Cefperazone-Sulbac-tam. For minocycline and Tigecyclinefor, the resistance rate was 5. 40%. For Pseudomonas aeruginosa to carboxy ampicillin the resistant rate was 13. 64%. For main gram-positive bacteria erythromycin, resistance rate to penicillin: Enterococcus faecalis was 14. 29%, 71. 43%, and staphylococcus hominis was 84. 21% and 84. 21%, Staphylococcus epidermis was 87. 88% and 78. 78%, Staphylococcus aureus was 57. 14% and 35. 71%. Conclusion BSI has underlying diseases in most cases. Clinical gram negative bacilli isolation rate and drug resistance rate are high. The local antibiotic use and management of drug resistance should be strengthened to reduce the occurrence of antibiotic resistance rate.