Changes of Serum PTX-3 in Patients with Acute Coronary Syndromes
MU Zhan
HU Wei-wei
WU Zhi-hong
YAN Shu-cai
DU Shu-juan
Abstract：Objective To explore the roles of PTX-3 in the assessment of the severity of acute coronary syndromes. Methods 90 patients with acute coronary syndrome were divided into unstable angina pectoris (UAP) group (n=26), ST segment elevation MI (STEMI) group (n=31), and non-ST segment elevation MI (NSTEMI) group (n=33) according to guidelines of ACC/AHA. 30 healthy volunteers were enrolled as control group. Serum PTX-3 level were measured with en-zyme-linked absorbed assay. The level of hs-CRP was determined by using an automated measurement method. Results The levels of PTX-3 and hs-CRP in UAP, STEMI and NSTEMI groups were significantly higher than those in the control group (P<0. 05). The levels of PTX-3 and hs-CRP in STEMI and NSTEMI groups were significantly higher than those in UAP group, all with significant differences ( P<0. 05 ) . There was no significant difference between STEMI group and NSTEMI group. Pearson collection analysis, serum PTX-3 level were positively correlated with the levels of total cholesterol ( TC) , tri-glyceride (TG), low density lipoprotein cholesterol (LDL-C) and hs-CRP (r=0. 484, r=0. 572, r=0. 587, r=0. 866;P<0. 01), was negatively correlated with the level of high density lipoprotein cholesterol (HDL-C) (r = -0. 497, P <0. 01). Conclusion The level of serum PTX-3 may play an important role in the pathogenesis of ACS and may be useful in assessment of the severity of acute coronary syndrome.
Keywords：Acute coronary syndromePentraxin-3C-Reactive Protein
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 68-71 )