Study on Apoptosis-Related Factors in Peripheral Serum of Patients with Hypertensive Disorder Complicating Preg-nancy

KONG Xiang-ling; WU Wei-guang; CHU Wei-wei

doi:10.3969/j.issn.1002-3429.2014.11.038

Abstract：Objective To investigate the changes of apoptosis-related factors in peripheral serum of patients with hy-pertensive disorder complicating pregnancy. Methods A total of 38 patients who suffered from gestational hypertension were chosen as hypertensive disorder complicating pregnancy group and 24 normal pregnant women were chosen as normal pregnancy group. The patients in hypertensive disorder complicating pregnancy group were divided into three groups: gestational hyper-tension group (14 patients), mild preeclampsia group (14 patients) and severe preeclampsia group (10 patients). Before ce-sarean section, vascular endothelial growth factor ( VEGF) , placenta growth factor ( PLGF) and GATA-3 in the normal preg-nancy group and hypertensive disorder complicating pregnancy group were detected for comparisons. Results The concentra-tions of VEGF and PLGF were markedly lower in hypertensive disorder complicating pregnancy group than those in normal pregnancy group, but GATA-3 was higher than that in normal pregnancy group, and the differences were all significant ( P<0. 05 ) . Peripheral blood concentrations of VEGF and PLGF in the 3 groups of gestational hypertension disease decreased with the degree of the disease, but GATA-3 concentration increased, and the differences among the three groups showed signifi-cance (P<0. 05). Correlation analysis results showed that GATA-3 was negatively related to VEGF between the mild and se-vere preeclampsia group (r= -0. 681, P=0. 044; r= -0. 741, P=0. 041). Conclusion Unbalanced peripheral blood concentration of apoptosis-related factors may be related to gestational hypertension disease.