Changes of N-Terminal-Pro-B-Type Natriuretic Peptide and Serum Cystain C in Elderly Patients with Chronic Heart Failure and Coronary Artery Disease
ZHU Hong
FENG Ming
LI Yun
Qian Yu-ying
LIU Chuan
Abstract：Objective To evaluate changes of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) and serum cystain C( Cys-C) in elderly patients with chronic heart failure( CHF) and coronary artery disease, and explore their correla-tion and clinical significance. Methods A total of 54 elderly CHF patients with coronary artery disease who were treated in Department of Geratology from October 2012 to September 2013 were selected as CHF group. And 30 elderly patients with cor-onary artery disease and compensated heart function were selected as control group. According to the New York Heart Associa-tion ( NYHA) cardiac functional standard, 54 patients in CHF group were divided into NYHA Ⅱ group and NYHA Ⅲ-Ⅳgroup. NT-proBNP as well as serum Cys-C level in CHF group and control group was compared. Those between NYHAⅡand NYHA Ⅲ-IV group were also compared. NT-proBNP influence factors were analyzed. Results Left ventricular end-diastolic dimension( LVEDD) , serum creatinine, blood urea nitrogen, serum NT-proBNP and Cys-C level in CHF group were signifi-cantly higher than those in control group (P<0. 05 or P<0. 01), but left ventricular ejection fraction (LVEF) and albumin were significantly lower than those in control group (P<0. 05 or P<0. 01). Serum NT-proBNP and Cys-C level in NYHAⅡgroup were significantly lower than those in NYHAⅢ-Ⅳgroup (P<0. 05 or P<0. 01). Pearson correlation analysis showed that NT-proBNP was positively correlated with age, serum Cys-C, serum creatinine, blood urea nitrogen and LVEDD;but NT-proBNP was negatively correlated with BMI, LVEF and eGFR. Multiple linear regression analysis showed that BMI, Cys-C and eGFR were independently correlated with NT-proBNP. Conclusion NT-proBNP and serum Cys-C level have obvious correlation in elderly CHF patients with coronary artery disease. Both are good indicators in evaluating the severity of CHF and reflecting the heart function.
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Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 95-98 )