Effects of Hemodilution on Cerebral Oxygen Metabolism in Rats with Severe Traumatic Brain Injury and Hemorrhagic Shock
ZHANG Zhan-boa
WANG Li-junb
FAN Li-bina
LIU Cai-xiac
Abstract：Objective To investigate the effect of hemodilution on cerebral oxyen metabolism in the rat model of trau-matic brain injury ( TBI) complicated by hemorrhagic shock. Methods A total of 30 male SD rats were randomly divided into 3 groups:TBI group (n=10), shock group (n=10), and TBI and shock group (n=10). SaO2, CaO2, hemoglobin and PbrO2 were determined after model establishment and 15 min, 30 min and 45 min after hemodilution. Results There were no signifi-cant differences of SaO2 at different time points among the three groups (P>0. 05). At 15 min, 30 min and 45 min after fluid infusion, the levels of hemoglobin, CaO2 and PbrO2 decreased significantly in shock group and shock and TBI group ( P <0. 05), especially at 15 min, but it rose again at 30 min and 45 min. Both groups were not at the range of blood transfusion. Af-ter successful molding, PbrO2 in TBI and shock group was lower than that in other two groups (P<0. 05, P<0. 01). Only PbrO2 showed significant differences between shock group and TBI and shock group at different time points after hemodilution (P<0. 05, P<0. 01), and it decreased significantly in TBI and shock group (P<0. 01). Conclusion The fluid resuscitation may aggravate hypoxic cerebral injury after traumatic brain injury (TBI) with hemorrhagic shock, although regular treatment.
Keywords：HemodilutionBrain injuriesShockhemorrhagicCerebral oxygen metabolismRatsSprague-Dawley
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 100-102 )