The Fixed-Value of FEV1/FVC <0. 7 in Diagnosis of Chronic Obstructive Pulmonary Disease:A Diagnostic Meta-analysis
XU Bei-zheng
LUO Yong
PAN Shu-ming
GE Xiao-li
PANG Yu-feng
Abstract：Objective To assess the reliability of fixed-value of FEV1/FVC <0. 7 (GOLD standard) in diagnosis of chronic obstructive pulmonary disease ( COPD) by meta-analysis. Methods By using FEV1/ FVC, FEV1 and LLN as retrie-ving words, MEDLINE, EMBASE and Cochrane libraries were searched for studies comparing FEV1/FVC<LLN and GOLD standard for COPD diagnosis between January 1966 and September 2012. By using RevMan 5. 1 and Meta-DiSc software, the meta-analysis was performed for the included articles which met the inclusion and exclusion criteria. Results Of 1877 identi-fied studies, 6 studies and 47 092 cases were included. For GOLD standard, sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 0. 90 (95%CI:0. 89-0. 90), 0. 92 (95%CI:0. 91-0. 92), 14. 55 (95%CI:9. 22-22. 97), 0. 06 (95%CI:0. 03-0. 15), and 259. 12 (95%CI:150. 76-445. 37), respectively. Good summa-ry receiver operator characteristic with an area under the curve of 0. 9827 and a Q point of 0. 9424 were observed. Two studies about the impact of age with GOLD standard in the diagnosis of airflow limitation were made meta-analysis, and the results showed that diagnosis parameters decreased with age, such as specificity, positive likelihood ratio and diagnostic odds ratio. Conclusion The value of FEV1/FVC <0. 7 remains useful preliminary diagnostic assessment for COPD with high reliability in most populations, but it may lead to increasing misdiagnosis rate with age in elder patients.
Keywords：Pulmonary diseasechronic obstructiveForced expiratory volumeVital capacityLower limits of nor-malDiagnosisMeta-analysis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 67-71 )