Therapeutic Effects of Combined Cisplatin and Paclitaxel versus Cisplatin and Fluorouracil Regimen with Concurrent Radiotherapy for Locoregionally Advanced Laryngeal Cancer
CHI Feng
XIAO Yu-Ping
ZENG Yue-can
CHEN Jia-jia
WU Rong
XING Rui
CAI Wei-song
WU Li-na
WANG Si-liang
CHEN Huan-huan
Abstract：Objective To explore the therapeutic effects and adverse effects of the two regimens:paclitaxel and cis-platin ( TP regimen) , cisplatin and fluorouracil ( PF regimen) , both with concurrent radiotherapy for the treatment of locore-gionally advanced laryngeal cancer. Methods Forty-seven patients with locoregionally advanced laryngeal cancer were ran-domly divided into the TP group (n=24) and the PF group (n=23). All the patients received conventional radiotherapy at a total dose of 60-70 Gy in primary tumor and metastatic lymph nodes for 6-7 weeks (2. 0 Gy/d, 5 times per week). Both groups received four cycles of chemotherapy, two cycles during radiotherapy and two cycles after radiotherapy, respectively. In TP group, the patients received intravenous infusion of paclitaxel (135 mg/m2 ) on day 1 and cisplatin (25 mg/m2 ) on days 1-3, with every 28 days as one cycle. PF regimen consisted of cisplatin (25 mg/m2 ) on days 1-3 and continuous intravenous infusion of fluorouracil (500 mg/m2 ) on days 1-5, with every 28 days as one cycle. The short-term effects and adverse effects were observed after therapy, and median survival time was observed during the 5-year follow-up. Results There was a signif-icant difference of short-term efficacy between the two groups (P<0. 05). The adverse effects including radiation induced lar-yngitis, gastrointestinal reactions and myelosuppression showed significant differences between the two groups (P<0. 05). The median survival time was 2. 4 year in TP group and was 2. 0 years in PF group (P>0. 05). Conclusion TP regimen with concurrent radiotherapy has a high effective rate and better patient tolerance in the treatment of locoregionally advanced la-ryngeal cancer.
Keywords：Laryngeal neoplasmsChemoradiotherapyPaclitaxelCisplatinFluorouracil
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 25-28 )