Expression of Pigment Epithelium-Derived Factor at Different Stages of Type 2 Diabetic Nephropathy
CAO Wei-guang
LIU Shan
WANG Zhan-jian
Abstract：Objective To observe the expression level of urinary pigment epithelium-derived factor ( PEDF) at differ-ent stages of type 2 diabetic nephropathy ( DN) and its relationship to disease condition. Methods 120 type 2 diabetic pa-tients were divided into four groups(30 patients per group), including simple diabetes mellitus group (T2DM group), type 2 diabetic nephropathy stage Ⅲ group( DN Ⅲ group) , type 2 diabetic nephropathy stage Ⅳ group( DN Ⅳ group) , and type 2 diabetic nephropathy stageⅤgroup( DNⅤgroup) . 30 healthy people with medical examinations at the same time were chosen as control group. Urinary PEDF in the 5 groups were detected for comparisons. Results The urinary PEDF was (1. 13 ±0.39)μg/ml in control group, (4. 57 ±0. 47)μg/ml in T2DM group, (6. 88 ±0. 79)μg/ml in DNⅢ group, (8. 52 ±0. 77)μg/ml in DNⅣ group and (5. 70 ±0. 64)μg/ml in DNⅤgroup, respectively. PEDF level in T2DM group, DNⅢgroup, DNⅣgroup and DNⅤgroup was significantly higher than that in the control group(P<0.05),and it increased with the severity of the disease in T2DM group, DNⅢgroup and DNⅣgroup, and the differences among the 3 groups were significant (P<0.05). PEDF level in DNⅤ group was lower than that in DNⅢ group and DNⅣ group, but higher than that in T2DM group, and the differences were significant ( P<0.05 ) . Conclusion The urinary PEDF level in patients with diabetic ne-phropathy may change in early phase and change gradually with progression of disease. It can be a sensitive marker in diagno-sing diabetic nephropathy at early stage.
Keywords：Type 2 diabetes mellitusDiabetic nephropathyUrinePigment epithelium-derived factor
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 99-101 )