Changes of Blood Lactic Acid in Acute Ischemic Stroke during Primary Period
LI Bin
HU Xiao-feng
LIU Jia-fu
LI Hao-jun
FAN Xiao-li
PAN Shu-ming
WANG Hai-rong
Abstract：Objective To study the changes of blood lactic acid in acute ischemic stroke (AIS) and its diagnostic val-ue. Methods A total of 148 AIS inpatients within 4. 5 h after onset during April 2011 and March 2013 were chosen as AIS group, and 51 volunteers taking health examination at the same period were as control group. The level of blood lactic acid was measured at once after admission in AIS group and the day receiving health examination in control group. The values of blood lactic acid was obtained by drawing receiver operating curve (ROC) in the two groups and were compared, and the best cutoff value assisting diagnosis and the relationship between value of blood lactic acid in AIS group with score of United States National Institutes of Health Stroke Scale (NIHSS) were also analyzed. Results The value of blood lactic acid (2. 09 ± 0. 75)mmol/ L in AIS group at once after admission was significantly increased, compared with (1. 65 ±0. 53)mmol/ L in control group (t =4. 60, P =0. 0 001); the best cutoff value assisting diagnosis of blood lactic acid was 1. 85 mmol/ L; there was no relationship between value of blood lactic acid and NIHSS score (r =0. 128, P =0. 121). Conclusion Blood lactic acid may be one of ear-ly biomarkers in diagnosis of acute ischemic stroke, and the increasing value may be helpful in diagnosis of acute ischemic stroke in primary period.
Keywords：Ischemic strokeLactic acidThrombolytic therapy
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 113-115 )