Influence of Cilostazol on Interleukin-6 and Malondialdehyde after Treatment of Intracranial Aneurysm Ruptured by Interventional Therapy
ZHANG Zong-yin
ZHANG Zi-yin
TANG Jian-jian
LUO An-zhi
LONG Hong-chuan
HUANG Zhi-min
WU Yun
WANG Min
Abstract：Objective To explore the influence of Cilostazol on interleukin-6 (IL-6) and malondialdehyde (MDA) af-ter treatment of intracranial aneurysm (IA) ruptured by interventional therapy. Methods A total of 100 IA aneurysm ruptured patients undergoing interventional therapy during May 2009 and October 2012 were divided into Cilostazol treatment group (treat-ment group, n =32) and non-Cilostazol treatment group (control group, n =68). The levels of serum IL-6 and MDA in the two groups were compared on the admission day, 10th d, 20th d and 30th d after intravascular therapy. Results The levels of serum IL-6 and MDA in treatment group gradually decreased to normal 20th d after operation, and the decreased rate in treatment group was significantly higher than that in control group (t =7. 05, P <0. 05; t =6. 12, P < 0. 05). Conclusion Cilostazol medica-tion after treatment of IA ruptured by interventional therapy may effectively reduce the incidence rates of systemic inflammation and stress response, but the effect of prevention of aneurysm ruptured recurrence needs to be further studied.
Keywords：Intracranial aneurysmAneurysmrupturedInterleukin-6MalondialdehydeComplicationAngiospasmintracranial
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 104-106 )