Clinical Value of Urinary α1-microglobulin Detection in the Early Diagnosis of Renal Damage

HUANG Qiong-lian; QIN Xi; LI Hao; HAN Feng; PAN Wan; HE Jin-long

doi:10.3969/j.issn.1002-3429.2014.07.040

Abstract：Objective To explore the value of urinary α1-microglobulin (α1-MG) detection in the early diagnosis of renal damage. Methods A total of 73 patients with renal damage in early period during December 2013 and April 2014 were selected as nephropathy group, who were divided into positive urinary protein subgroup (group A, n = 44) and negative urina-ry protein subgroup (group B, n = 29) according to the urinary protein level, and 40 healthy persons at the same time were chosen as control group. Urina sanguinis were collected in the two groups. In the two groups, the levels of α1-MG and β2-mi-croglobulin (β2-MG) were detected by immune rate nephelometry to compare the correlation and positive rate of the two lev-els, and diagnostic efficacy was evaluated using receiver operating curve (ROC). Results The levels of α1-MG and β2-MG in nephropathy group were significantly higher than those in control group, and the differences were statistically significant (U = 16. 00, P = 0. 000; U = 576. 50, P = 0. 000); urinary α1-MG positively correlated with β2-MG ( r = 0. 732, P =0. 000). The positive rates of urinary α1-MG and β2-MG in nephropathy group were 84. 93% and 69. 8% respectively, and the difference was statistically significant (χ2 = 4. 737, P = 0. 030), but the difference in positive rate in the positive urine protein subgroup was not statistically significant (χ2 = 3. 138, P = 0. 064), and the difference in positive rate in the negative urine protein subgroup was not statistically significant (χ2 = 1. 758, P = 0. 185). The diagnostic efficacy analysis showed that the accuracy level of α1-MG was higher than that of β2-MG. Conclusion Urinary α1-MG and β2-MG has high diagnostic ac-curacy for renal damage in early period, α1-MG is less influenced by the laboratory temperature and urine pH, and the sensi-tivity is higher than that of β2-MG, so α1-MG may be more suitable for diagnosis of renal damage in preliminary period.