Clinical Value of NT-proBNP on the Prognosis of Patients with Sepsis
CHENG Hui
WANG Sheng-chi
ZANG Hui-ling
FAN Wei-ze
WANG Li-zhong
LIU Hong-juan
SHEN Xiao-hui
LIANG Shao-qing
Abstract：Objective To evaluate the prognosis value of immunoreactive amino-terminal pro-brain natriuretic peptide (NT-proBNP) on patients with sepsis. Methods A total of 60 sepsis patients admitted during January 2011 and June 2013 were divided into survival group (n = 42) and death group (n = 18) based on the survival status on the 28th d after admission. Serum NT-proBNP levels within 2 h after admission and APACHE II (acute physiology and chronic health evaluation II) scores within 24 h after admission in the two groups were compared, and the value of NT-proBNP on prognostic assessment of sepsis patients were investigated by establishment of the ROC curve of work characteristics. Results The serum level of NT-proBNP in death group (5873. 24 ± 1768. 37)pg/ ml was significant higher than (2170. 45 ± 625. 28) pg/ ml in the survival group, and the difference was statistically significant (t = 2. 660, P = 0. 015); APECHE II score of (26. 47 ± 5. 32) in death group was significantly higher than (21. 54 ± 4. 35)in survival group, and the difference was also statistically significant (t =2. 390, P = 0. 020). Pearson correlation analysis indicated that the serum NT-proBNP level had a positive correlation with APACHE II score (r = 0. 509, P = 0. 003). The area under the ROC curve for NT-proBNP level and APACHE II score were 0. 730 and 0. 715 respectively, which had a similar prognosis assessment value in sepsis patients. Conclusion NT-proBNP has a better clinical value on the prognosis assessment of sepsis patients, and can be served as a reference index for the prog-nosis evaluation in sepsis patients.
Keywords：SepsisNT-proBNPAPACHE II scorePrognosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 16-18 )