Influence of Metformin on Serum C-reactive Protein and Lipid Level in Patients with Type 2 Diabetes Mellitus
SU Hong
SUN Meng-meng
ZHAO Yue-ping
HU Xiao-fang
Abstract：Objective To observe the changes of serum C-reactive protein (CRP) and lipid level before and after Metformin therapy in patients with type 2 diabetes mellitus. Methods A total of 84 patients with primary type 2 diabetes mel-litus were randomly divided into treatment group (n=42) and control group (n=42). The two groups received individual di-et, exercise scheme and oral Gliclazide Modified Release tablets, and the treatment group was added with Metformin based on the treatment. Changes of serum CRP and lipid level before treatment and after 36 and 72 weeks of treatment in the two groups were observed. Results After 36 and 72 weeks of treatment, levels of serum CRP, total cholesterol (TC), triglyceride ( TG) and low density lipoprotein cholesterol ( LDL-C) were significantly lower in treatment group, compared with those before treatment and in control group (P<0. 05);the level of high density lipoproteins (HDL-C) was significantly higher, compared with those before treatment and in control group (P<0. 05);the differences in levels of serum CRP, TC, LDL-C and HDL-C showed no statistical significances in control group before and after the treatment (P>0. 05). Conclusion Metformin can relieve IGT vascular inflammatory reaction and reduce the concentration of serum lipid level in patients with type 2 diabetes mellitus.
Keywords：Diabetes mellitustype 2MetforminC-reactive proteinBlood fat
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 95-98 )