Auxiliary and Regulatory T cells Expression in Peripheral Blood and Lesion Microenvironment of Patients with Tri-ple-negative Breast Cancer
LONG Fei
JIANG Da-qing
ZHANG Xin-feng
WANG Cong
LI Yang
Abstract：Objective To analyze the levels of the auxiliary and regulatory T cells expression in peripheral blood and lesion microenvironment of patients with triple-negative breast cancer ( TNBC ) . Methods The levels of auxiliary T cells (CD3 +, CD4 +, CD8 +, CD4 + /CD8 +) and regulatory T cells (CD4CD25 + Treg and CD4 + CD25 + Foxp3 + Treg) in periph-eral blood and lesion microenvironment were detected for 34 TNBC patients ( TNBC group) confirmed by clinical and patholog-ical results, 39 non-TNBC patients ( NTNBC group) and 27 patients with benign breast diseases ( control group) from 2012 January to April, and the levels in the three groups were also compared. Results In the TNBC group, the levels of CD3 +, CD4 + and CD4 + /CD8 + were significantly lower than those in the NTNBC and control groups, but the CD8 + level was signifi-cantly higher than that in the NTNBC and control groups (P <0.05); the levels of CD4CD25 + Treg and CD4 + CD25 +Foxp3 + Treg in the TNBC group were significantly higher than those in the NTNBC and control groups (P<0.05). Conclu-sion The auxiliary and regulatory T cells are abnormally expressed in the peripheral blood and lesion microenvironment in TNBC patients, which is a characteristic parameter of immunology in etiological diagnosis and evaluation effect, wihich may provide test data to find a method of TNBC immunotherapy in the future.
Keywords：Breast neoplasmT-LymphocyteregulatoryT-lymphocytehelper-inducerBloodTumor microenvi-ronment
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 67-70 )