Interferon-γRelease Assay in Diagnosis of Tuberculosis Infection:a Meta-analysis
ZHANG Zhao-yong
ZHANG Ji-cai
LYU Jun
XIE Fei
WANG Yuan-yuan
Abstract：Objective To evaluate the application value of interferon-γrelease assays ( IGRA) in diagnosis of myco-bacterium tuberculosis infection. Methods All Chinese studies about IGRA in diagnosis of mycobacterium tuberculosis infec-tion during January 1994 and June 2013 were retrieved from CbmWin, CNKI and Wanfang databases. Two researchers a-chieved studies screening and data fetch independently, and then data analysis were conducted by meta-Disc1. 4 software after discrepancy studies were removed. Results Seventeen studies with 1799 patients and 885 controls were included in this stud-y. The results of meta-analysis showed that the sensitivity of mycobacterium tuberculosis was 86% [95% confidence interval (CI) :0. 85-0. 88];specificity was 86% (95% CI:0. 83-0. 88); positive likelihood ratio (LR) was 6. 06 (95% CI:4.76-7.70);negative LR was 0. 12 (95% CI: 0. 09 -0. 18) and diagnosis odds ratio (DOR) was 58. 67 (95% CI:35.37-97.31). Area under the curve (AUC) of fitting the summary receiver operating characteristic (SROC) was 0. 9457 and Q* =0. 8848. Conclusion Whole-blood interferon-γ release assays has good sensitivity and specificity in diagnosis of mycobacterium tuberculosis infection, and can be used as an effective method in clinical diagnosis of TB.
Keywords：Interferon-γ release assayMycobacterium tuberculosisInfectionDiagnosisMeta-analysis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 41-44 )