Disfunction of Transplanted Kidney Induced by Drugs:a Report of Two Cases and Literature Review
NIE Fenga
HUANG Zhi-chenga
YANG Jian-juna
SUN Xu-yongb
TAN Qingc
QIN Keb
HUANG Chenb
Abstract：Objective To explore clinical manifestations and the key points of treatment of disfunction of transplanted kidney induced by drugs so as to enhance awareness and reduce misdiagnosis rate. Methods Clinical data of 2 cases of dis-function of transplanted kidney induced by the renal toxicity drugs was retrospectively analyzed, and pertinent literature was al-so reviewed. Results Two male patients had pulmonary infection after kidney transplantation, and were treated with Vanco-mycin including one added with Amphotericin B as anti-infective therapy after immunosuppressive agents were stopped. Dis-function of transplanted kidney was found after the 15th and 20th d of pharmacotherapy. The patients mainly had hypourocrinia and serum creatinine increase, and were misdiagnosed as having acute rejection, but anti-rejection treatment was ineffective, and acute rejection was denied after pathological examination, and then disfunction of transplanted kidney induced by drugs was confirmed. One patient's renal function recovered after use of Vancomycin was stopped, and transplanted kidney of another patient was excised due to failure of recovery of renal function. Conclusion Disfunction of transplanted kidney induced by the renal toxicity drugs is lack of specific symptoms and can easily be misdiagnosed. Clinicians should enhance awareness of the disease, and pathological examination is key to definite diagnosis and treatment.
Keywords：Kidney transplantDrug toxicityRenal toxicityMisdiagnosisAcute rejectionPathological examination
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 20-23 )