Clinical Effectiveness of Combined Treatment of Traditional Chinese Medicine and Western Medicine in Treatment of Hyperprolactinemia:A Meta-analysis

XIN Yu; LU Jia-peng; CHEN Di; WANG Bin

doi:10.3969/j.issn.1002-3429.2014.05.035

Abstract：Objective To evaluate the effect of combined treatment of traditional Chinese medicine and western medi-cine in treatment of hyperprolactinemia( HPRL). Methods Relevant literature of combined treatment of traditional Chinese medicine and western medicine in treatment of HPRL published during January 1991 and December 2013 was retrieved in Pubmed,EMbase,Medline,EMBR,CNKI,VIP and Wanfang database. The efficacy,post-treatment level of serum prolactin ( PRL)and adverse reaction were comparatively analyzed with system evaluation and meta-analysis between combined treat-ment of traditional Chinese medicine and western medicine group( treatment group ) and western medicine group( control group). Results A total of 9 papers were recruited in this study,including 816 hyperprolactinemia patients,and 423 patients were in treatment group and 393 patients in control group. The meta-analysis showed that the total effective rate in treatment group was significantly higher than that in control group(RR =1. 06,95% CI:1. 01 -1. 11,Z =2. 32,P =0. 02);serum PRL level on the time of drug withdrawal and 6 months after drug withdrawal in treatment group was significantly lower than those in control group(SMD-1. 82,95%CI:-3. 49-0. 16,Z=2. 14,P=0. 03;SMD-14. 06,95%CI:-19. 24--8. 88, Z=5. 32,P﹤0. 00001);the incidence rate of adverse reaction in treatment group was significantly lower than that in control group(RR=0. 20,95% CI:0. 10 -0. 42,P ﹤0. 0001). Conclusion Combined treatment of traditional Chinese medicine and western medicine in treatment of HPRL is more effective with a lower incidence rate of adverse reaction compared with that of western medicine therapy.