Significance of Ganglioside in Cerebral Preventive Therapy of Acute Carbon Monoxide Poisoning in Early Period
XIAO Jian-bo
WANG Li-he
FU Guo-qiang
CAO Yi-zhan
WANG Bo-liang
Abstract：Objective To investigate the significance of ganglioside(GM-1)in cerebral protective therapy of delayed encephalopathy after acute carbon monoxide poisoning( DEACMP)in early period of acute carbon monoxide( CO)poisoning. Methods A total of 86 patients with acute CO poisoning were randomly divided into control group(n =43)and treatment group(n=43). Conventional treatments of hyperbaric oxygen,microcirculation improvement and trophic nerve were given to the two groups,and the treatment group was added with GM-1 based on the treatments. The length of hospital stay,treatment effectiveness and drug adverse reaction in the two groups were observed,and incidence rates of DEACMP 2 weeks after treat-ments were also observed. Results In the treatment group,the length of stay was shorter,the total effective rate was higher, and incidence rate of DEACMP 2 weeks after treatments was lower than those in control group,and the differences were statis-tically significant(P﹤0. 05). There was no drug adverse reaction during the treatments in the two groups. Conclusion Early use of GM-1 in cerebral protective therapy of acute CO poisoning can improve the total effective rate and reduce the incidence rate of DEACMP without obvious adverse reactions. .
Keywords：Carbon monoxide poisoningGanglioside
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 72-74 )