Synthesis and herbicidal activity of 5-(1-Amino-2-phenoxybutylidene)barbituric acid derivatives containing a maleimide moiety
HAN Shibo
CHEN Ke
WANG Shumin
FU Shuyue
GAO Wei
LEI Kang
Abstract：In order to discover herbicide lead compounds with novel structure and high activity,nineteen 5-(1-amino-2-phenoxybutyliene)barbituric acid derivatives containing a maleimide moiety were designed and synthesized,and their herbicidal activities were evaluated in the greenhouse.The bioassay data showed that most of the target compounds exhibited moderate to good growth inhibition against the tested weeds at the dose of 1 200 g/ha under the post-emergence condition.Among them,the target compound BTA-13 exhibited excellent herbicidal activity against the weeds tested with sum inhibition rate 293％,even at a dosage of 150 g/ha,which was comparable to the commercial herbicide-Fluminate.The studies of herbi-cidal spectrum and crop safety revealed that the target compound BTA-13 had a broad herbicidal spectrum,and it was determined to be safe for maize and wheat at a dose of 150 g/ha under the post-emergence condi-tion,which indicated that the target compound BTA-13 had the potential to be developed into herbicide.The present work demonstrates that the target compound BTA-13 can serve as a lead compound for further development of novel herbicides.
Keywords：barbituric acidmaleimideenamino diketoneherbicides
Publication Date：2025-12-31
Online Publishing Date：2026-08-28(First online date of this platform, not the publication date of the document)
Pages：12( 976-987 )