Advances in miscibility prediction and performance optimization of amorphous solid dispersions based on polymer selection
QU Beibei
WU Hengqian
DING Zhuang
HAN Jun
WU Chuanyu
WANG Zhengping
Abstract：Amorphous solid dispersion(ASD)have attracted considerable attention in drug delivery as a key strategy for enhancing the solubility and bioavailability of poorly soluble drugs.Polymer selection plays a pivotal role in ASD systems,directly influencing drug-polymer miscibility,stability,and overall formulation performance.Consequently,accurately predicting drug-polymer miscibility and selecting suit-able polymers based on specific performance requirements are of significant research interest in ASD opti-mization.This review highlights the critical role of polymer selection in ASDs,systematically summarizes both predictive and experimental methods for assessing drug-polymer miscibility,and comprehensively ex-amines various performance optimization strategies,including,recrystallization inhibition,dissolution en-hancement and stability improvement.By providing theoretical insights into the rational design of ASDs,this review aims to facilitate their broader application in the delivery of poorly soluble drugs.
Keywords：amorphous solid dispersionpolymer selectionmiscibility predictionperformance optimiza-tiondrug delivery
Publication Date：2025-12-31
Online Publishing Date：2026-08-28(First online date of this platform, not the publication date of the document)
Pages：10( 966-975 )