Research Progress on the Modulation of Immunity by Combining Exogenous Stimulation to Promote Bone Regeneration
ZHANG Xue
LANG Yufan
ZHAO Hang
LIU Siyu
DUAN Yi
LUO Weihua
Abstract：Bone tissue engineering scaffolds,when implanted in the body,often trigger a series of different degrees of inflammation affecting the outcome of bone repair treatment.At present,clinics usually consid-er loading various bioactive factors(including various small molecule drugs,cytokines,etc.)on the scaf-folds to improve this problem,but this method,in addition to the uncontrollability,will also trigger the occurrence of resistance,toxicity and other side effects in the human body due to dosage problems,in-creasing the cost of treatment and decreasing the effectiveness of bone regeneration therapy.In this paper,we review the current research status of combining near-infrared light,electricity,magnetism,ultrasound and other exogenous stimulation of spatiotemporal modulation of the immune microenvironment to pro-mote bone regeneration in recent years,analyze its current problems and shortcomings,and put forward a prospect for the future research and clinical application.
Keywords：exogenous stimulationspatiotemporal regulationimmune microenvironmentbone regenera-tion
Publication Date：2025-04-27
Online Publishing Date：2026-08-28(First online date of this platform, not the publication date of the document)
Pages：8( 278-285 )