Progress of O-GlcNAc Modification
WANG Menghe
ZHENG Lu
MENG Linghang
WANG Jiajia
Abstract：Protein O-GlcNAc glycosylation,a type of O-linked monosaccharide modification,involves theβ-linkage of GlcNAc to serine or threonine residues of cytoplasmic or nuclear proteins,which is widely found in eukaryotic cells.O-GlcNAc modification participates in a large account of biological processes,including gene expression,signal transduction,immunoprotection and cell metabolism,et al.,Aberrant O-GlcNAc modification will lead to various diseases,such as diabete,cancer,angiocardiopathy and neuro-degeneration.Moreover,identification of O-GlcNAcylated proteins will facilitate to understand the regula-tory mechanism in associated diseases.It is very difficult to identify the O-GlcNAc modification site in MS with low responsive signals because O-GlcNAcylation is a dynamic and stoichiometric modification.Here,in this paper,we will summarize the important roles of O-GlcNAcylation in biological processes,as well as the enrichment methods for O-GlcNAc modification,which will provide methods for researchers to in-vestigate O-GlcNAcylation.
Keywords：O-GlcNAc modificationmolecular probesmetabolic labeling
Publication Date：2024-02-28
Online Publishing Date：2026-08-28(First online date of this platform, not the publication date of the document)
Pages：10( 92-101 )