Investigation of serum Helicobacter pylori antibodies and pepsinogen in aircrews

ZHANG Liyun; WANG Tianhua; SONG Qingling; SUN Jujiang; GENG Yan; DAI Qing; DU Lei

doi:10.3969/j.issn.2097-1753.2025.06.007

Abstract：Objective To investigate the distribution of serum Helicobacter pylori IgG antibodies and its impact on PG Ⅰ,PGⅡand PGR level in aircrew.Methods A total of 325 military aircrew who underwent health examinations at the Lintong Rehabilitation and Convalescent Center from April 2017 to August 2017 were enrolled in the study.Based on Helicobacter pylori antibody test results,they were divided into the positive group(107 cases)and the negative group(218 cases).Additionally,92 ground crews who underwent health examinations from December 2016 to December 2017 were selected as the control group.Differences in Helicobacter pylori antibody positivity rates among aircrew members of varying ages and aircraft types were analyzed.Furthermore,serum pepsinogen levels were compared across different Helicobacter pylori antibody positivity statuses.Results Positive results Helicobacter pylori IgG antibodies test in aircrew accounts for 32.92％,with the statistically significant difference among all groups(x2=11.957,P=0.008).Infection rate in the age 41～50 group were significantly higher than the group of age less than 30(P＜0.05).Positive results of Helicobacter pylori IgG antibodies test in ground crews accounts for 29.35％with no statistically significant difference among all groups.There was no significant difference between different aircrafts(P＞0.05).Additionally,positive Helicobacter pylori IgG antibodies group showed significantly higher level of PGⅡ and lower PGR values(Z=3.072,3.224,P=0.002,0.001).Conclusion Infection with Helicobacter pylori might have an influence on the level of serum pepsinogen.The analysis of serum Helicobacter pylori IgG antibodies and pepsinogen may give us the guidance in evaluating the gastric mucosal status.