Quantifiable physiological indicators for identification of severity of hypoxia
WANG Liping
YU Lihua
ZHANG Yan
SHI Weiru
WEN Dongqing
GONG Wenjing
LENG Xueqi
JIA Fenglin
XUE Lihao
Abstract：Objective To study the changes in physiological indicators of the human body in hypoxic environments and explore the physiological indicators that can be quantified to assess the degree of hypoxia.Methods In October 2023,16 male staff members from the Air Force Medical Center were selected as the subjects and were randomly divided into a sedentary group and a mental workload group.Hypoxia tests were conducted at simulated altitudes of 1 500,2 500,3 000,4 000,5 000,6 000,7 000,and 7 500 m in the hypobaric chamber.Results The results of multiple linear regression analysis showed that levels of blood oxygen saturation impacted the duration of hypoxia(B=3.283,95％CI:1.896-4.670).The curves for changes in levels of blood oxygen saturation with the duration of hypoxia at different altitudes were fitted,and the duration of hypoxia at which levels of blood oxygen saturation decreased to the target critical value at each altitude was determined.Conclusion During acute high-altitude hypoxia,the levels of blood oxygen saturation can make a difference in the duration of hypoxia.This study is expected to contribute to related identification,early warning and interventions.
Keywords：High-altitude hypoxiaDegree of hypoxiaQuantificationPhysiological indicatorsOxygen saturation
Publication Date：2025-12-25
Online Publishing Date：2026-03-31(First online date of this platform, not the publication date of the document)
Pages：5( 555-559 )