Research progress in roles of autophagy regulation in occurrence and development of major diseases and related interventions
JIN Yiling
WANG Wei
Abstract：Autophagy is a dynamic process involving changes in subcellular membrane structures, leading to the degradation of proteins and organelles within the cell through lysosome-mediated mechanisms. It is a regulatory mechanism for cellular homeostasis, and its dysfunction is closely related to the occurrence and development of various major diseases. This study reviews research on autophagy regulation based on animal models, focusing on the mechanisms of action and intervention progress of autophagy in tumors, neurodegenerative diseases, cardiovascular and cerebrovascular diseases, metabolic diseases, and skeletal diseases, aiming to provide new ideas and potential targets for future clinical research and disease prevention.
Keywords：Autophagy regulationSignal pathwayDisease treatment
Publication Date：2025-10-25
Online Publishing Date：2025-11-26(First online date of this platform, not the publication date of the document)
Pages：5( 516-520 )