Lipid and uric acid metabolism of aircrews based on intestinal flora
DU Lei
CHEN Yichen
MU Jing
WANG Boqiang
ZHAO Juan
LI Ya
DAI Qing
WANG Wenlan
Abstract：Objective To find out more about the differences in gut microbiota between aircrews with hyperlipidemia(HL),hyperuricemia(HA)or both(HA+HL)and healthy aircrews(NC).Methods A total of 40 aircrews who underwent physical examinations at our hospital between September 2022 and September 2023 were enrolled and divided into four groups:a normal control group(NC group,10 participants),a hyperlipidemia group(HL group,10 participants),a hyperuricemia group(HA group,10 participants),and a hyperlipidemia combined with hyperuricemia group(HA+HL group,10 participants).The basic demographic information,important data and metabolic indicators(including blood lipid parameters and serum uric acid levels)were collected.Fecal samples were obtained and subjected to 16S rDNA amplicon sequencing to analyze gut microbiota composition.Differential bacterial communities were identified before their functional characteristics were investigated.Results Based on the Bray-Curtis distance matrix,weighted differences between samples were calculated and analyzed using principal coordinate analysis(PCoA).The results showed that the microbial structures of the HA group,HA+HL group,and HL group were significantly different from those of the NC group(F=1.625,1.654,1.400,all P＜0.05).At the phylum level,the top five bacterial phyla across all four groups were Firmicutes,Bacteroidetes,Proteobacteria,Actinobacteria,and Desulfobacterota.The relative abundance of Firmicutes in the HA+HL group was significantly higher than in the NC group(P＜0.001),and that of Bacteroidetes and the Bacteroidetes-to-Firmicutes ratio in the HA,HL,and HA+HL groups were all significantly higher than in the NC group(all P＜0.001).At the genus level,the top eight gut bacterial genera across the four groups were Megamonas,Bacteroides,Faecalibacterium,Bifidobacteriaceae,Prevotella-9,Streptococcus,Agathobacter,and Escherichia-Shigella.Significant differences were observed in the abundance of Escherichia-Shigella between the four groups(H=9.000,P=0.029),with the relative abundance of the HA+HL group significantly lower than in the NC group(P＜0.05).Conclusion Aircrews with HA,HL or both(HA+HL)are vulnerable to gut microbiota dysbiosis.Alterations in the abundance of fermentative carbohydrate-related bacterial genera may serve as significant biomarkers for metabolic abnormalities.
Keywords：Intestinal floraHyperlipidemiaHyperuricemiaFermented carbohydrates
Publication Date：2025-10-25
Online Publishing Date：2025-11-26(First online date of this platform, not the publication date of the document)
Pages：6( 450-455 )