Advances in studies on regulation of NLRP3 inflammasome activation by sumoylation
NAN Yiqi
WANG Yueyue
YUAN Qinghong
CAI Sirui
YANG Kun
JIANG Dongbo
Abstract：Inflammasomes are multi-protein complexes that play an important role in inflammatory responses, and their activation is regulated and influenced by various factors. SUMOylation, a type of post-translational modification (PTMs), also plays an important role in the regulation of inflammasome activation. This review systematically summarizes the SUMOylation modifications of the NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome, elucidates the biological roles of various SUMO-modifying molecules and SUMO ligases in activating NLRP3, and summarizes the patterns of SUMOylation affecting NLRP3 inflammasome activation, providing new insights for regulating inflammasome activation and treating inflammasome-related diseases.
Keywords：SumoylationProtein processingpost-translationalNLRP3 inflammasome
Publication Date：2025-04-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 149-155 )