Effects of postoperative adjuvant steroid therapy on outcomes of type-Ⅲ biliary atresia

WANG Yetong; LI Long

doi:10.3969/j.issn.2097-1753.2025.02.007

Abstract：Objective To investigate the impact of steroid treatment on clinical outcomes and steroid-related complications in children with type Ⅲ biliary atresia after Kasai surgery.Methods A retrospective study was conducted on 112 children with type Ⅲ biliary atresia who had undergone Kasai surgery at the Children's Hospital Affiliated to Capital Institute of Pediatrics between July 2018 and July 2020.The children were divided into steroid and control groups,each with 56 cases.The two groups were compared in terms of the jaundice clearance rate,autologous liver survival rate,and the incidence of steroid-related adverse reactions at 6,12,and 24 months postoperatively before statistical analyses were performed.Results The jaundice clearance rate in the steroid group was significantly higher than that of the control group at 6,12,and 24 months postoperatively(x2=4.390,4.495,4.568,P=0.036,0.034,0.033).At 6 months postoperatively,there was no significant difference in autologous liver survival rates between the two groups(P＞0.05).However,at 12 and 24 months postoperatively,the autologous liver survival rate in the steroid group was significantly higher than that of the control group(x2=5.735,5.312,P=0.017,0.021).There were no significant differences between the two groups in the total complication rate,or the incidence of wound dehiscence and gastrointestinal bleeding(P＞0.05).Conclusion Adjuvant steroid therapy can effectively promote bile drainage and prolong the survival of the autologous liver in children with type Ⅲ biliary atresia after Kasai surgery,although its clinical value in improving short-term autologous liver survival rates is not significant.