Analgesic and anti-inflammatory effects of a self-heating TCM package and safety for transdermal administration

XU Fangchu; YANG Zhihui; DAI Bo; LIN Yang

doi:10.3969/j.issn.2097-1753.2024.01.011

Abstract：Objective To investigate the efficacy and safety of a self-heating Tengfu TCM package.Methods SD rats were divided into the normal control group,model control group,self-heating Tengfu TCM(3.06 g/kg)low,medium,and high dose groups(0.5 h,3 h,6 h),traditional Tengfu TCM package group(12.42 g/kg,0.5 h),and diclofenac diethylamine emulsion group(0.125 g)according to body weight.An acetic acid-induced pain model and a cotton ball granuloma hyperplasia model in rats were used respectively,and the number of twists,latency and cotton ball granuloma hyperplasia in rats were determined to reveal the differences between the self-heating Tengfu TCM low-,medium-,and high-groups on one hand and the traditional Tengfu TCM group and the diclofenac diethylamine emulsifier group on the other hand.The skin irritation and skin sensitization of self-heating Tengfu TCM packages were investigated via skin irritation tests in experimental rabbits and patch tests in guinea pigs.Results The medium-and high-dose self-heating Tengfu TCM packages Compared with the model control group,The difference was statistically significant(P=0.016,P=0.007);traditional Tengfu TCM group Compared with low-dose self-heating Tengfu TCM packages The difference was statistically significant(P=0.029).Comparison of latency in diclofenac diethylamide group with model control group,The difference was statistically significant(P=0.008),high-dose self-heating Tengfu TCM packages Granuloma weight Compared with the model control group The difference was statistically significant(P=0.016).The self-heating Tengfu TCM package caused no irritation or sensitization to the skin.Conclusion The self-heating Tengfu TCM package has properties of analgesia and anti-inflammation,and it is safe for transdermal administration.