Correlations of Killip classification with serum levels of miR-33,miR-122 and electrocardiogram QRS complex duration in patients with non-ST-segment elevation myocardial infarction

FAN Hongfen; FAN Sibin; ZHANG Lin

doi:10.3969/j.issn.2097-1753.2023.06.007

Abstract：Objective To study the relationships between Killip grading and serum levels of minimal microRNA-33(miR-33)and minimal microRNA-122(miR-122)as well as the QRS durations of electrocardiograms in patients with non ST segment elevation myocardial infarction so as to provide data for assessment of related diseases.Methods In this prospective case-control study,96 patients with myocardial infarction treated in Nanchong Central Hospital between October 2018 and January 2021 were selected as the observation group,who were divided into grade Ⅰ group(n=21),grade Ⅱ group(n=42),grade Ⅲ group(n=19),and grade Ⅳ group(n=14)based on Killip grading.Another 80 healthy adults who underwent physical examination in our hospital were selected as the control group.The serum levels of miR-33 and miR-122 and durations of QRS wave on electrocardiograms were compared between the two groups.Pearson correlation analysis was used to investigate the relationships between serum miR-33 and miR-122 levels,electrocardiogram QRS wave durations,and Killip grading in patients with coronary heart disease.Results There were statistically significant differences in serum levels of miR-33 and miR-122 and in QRS durations of ECGs between the control group and the observation group(F=72.16,56.81,23.40,all P＜0.001).The serum levels of miR-33 and miR-122 and the QRS durations of ECGs in Killip Ⅳ patients were higherthan those of the control group and those of patients of grade Ⅰ,Ⅱ and Ⅲ,and were higher in Killip Ⅲ patients than in the control group and in patients of grade Ⅰ and Ⅱ.These indexes were higher in Killip Ⅱ patients than in the control group and in patients of grade Ⅰ,and higher in Killip Ⅰ patients than in the control group.The differences were statistically significant(t=2.15-58.14,P＜0.05).Pearson correlation analysis showed that the serum levels of miR-33 and miR-122 and QRS wave durations of ECGs were positively correlated with Killip grading(r=0.411,0.398,0.428,all P＜0.001).Conclusion There is a positive correlation between serum miR-33,miR-122 levels,electrocardiogram QRS wave durations,and Killip grading in patients with coronary heart disease,which can provide reference for the assessment of conditions of non ST segment elevation myocardial infarction patients.