Effects of sulodexide combined with telmisartan on urinary protein, plasma protein and liver and kidney function in patients with primary membranous nephropathy

LUO Jinhui; ZHANG Hui

doi:10.3969/j.issn.2095-3402.2018.02.018

Abstract：Objective To investigate the effect of sulodexide combined with telmisartan on urinary protein, plasma protein and liver and kidney function in patients with primary membranous nephropathy. Methods The clinical data of 69 primary membranous nephropathy patients treated in our hospital between May 2014 and March 2016 was retrospectively analyzed. These patients were randomly divided into two groups: the control group with 34 cases who were treated with sulodexide alone, and the observation group with 35 cases who received sulodexide combined with telmisartan. The clinical efficacy was observed. Results Before treatment, there was no statistically significant difference in 24 h urinary protein content, plasma albumin, or liver and renal function indexes between the two groups (P>0.05). One month after treatment, 24 h urinary protein decreased sharply in both groups, while plasma albumin levels increased evidently, and the difference was of statistical significance(P<0.05). One month after treatment, Scr, Cys-C and PI of the renal artery were obviously improved in both groups, especially in the observation group, and the difference was significant between the two groups (P<0.05), but ALT and AST did not change significantly within either group or between the two groups (P>0.05). There were no significant changes in the level of glutamic pyruvic transaminase (ALT) and glutamic pyruvic aminotransferase (AST) in the 2 groups after 1 months of treatment, and there was no significant difference between the groups (P>0.05). The total effective rate of the observation group, which was higher than the control group, and the difference between the two groups was significant (P<0.05). Conclusion Sulodexide combined with telmisartan for primary membranous nephropathy can apparently reduce urinary protein, increase serum albumin levels, promote renal function, and have less influence on liver function.