Dynamic effects of 0.02% fluorometholone combined with sodium hyaluronate on lacrimal secretion and ocular surface environment in the treatment of moderate dry eye
LIN Jie
ZHANG Zhicheng
LUO Zhengjian
WANG Bin
LIN Sheng
Abstract：Objective To investigate and analyze the dynamic effects of 0.02% fluorometholone combined with sodium hyaluronate on lacrimal secretion and ocular surface environment in the treatment of moderate dry eye. Methods One hundred and twenty-six patients with moderate dry eye treated in our hospital between May 2013 and December 2015 were included in this study. Clinical data of all these patients was collected and these patients were divided into the observation group(n=63) and the control group(n=63) according to therapies. The control group received 0.02% fluorometholone, while the observation group received 0.02% fluorometholone combined with 0.02% sodium hyaluronate. Ocular surface disease index (OSDI), fluorescence integral(FI), breakup time of tear film (BUT) , schirmer I test (SIT) and the ocular surface environment in both groups were observed before and after treatment. Also, therapeutic efficacy and adverse reactions were compared between the two groups. Results There was no statistically significant difference between the two groups before treatment(P>0.05), but the difference in OSDI, RI, BUT and SIT was of statistical significance between the two groups after treatment (P<0.05). The total effective rate was markedly higher in the observation group than in the control group (P<0.05). Fewer patients presented adverse reactions in the observation group than in the control group (P<0.05). Conclusion 0.02% fluorometholone combined with sodium hyaluronate is an effective approach to moderate dry eye and is conducive to lacrimal secretion and the ocular surface environment. More effective hormone drugs need to be found in order to benefit patients with dry eye.
Keywords：fluorometholonesodium hyaluronatemoderate dry eyelacrimal secretion and ocular surface environmentdynamic effects
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 119-122 )