Clinical analysis of cholestasis of intrahepatic cholestasis in gestation with ursodeoxycholic acid tablets and adenosylmethionine disulfonic acid two in the treatment of pregnancy
ZHANG Liming
LI Suyu
WANG Yan'an
GUO Shu'ai
YAN Lijuan
DUAN Dongshi
Abstract：Objective To investigate the effect of bile stasis combined with ursodeoxycholic acid tablets and ademetionine1,4-butanedisulfonate on the treatment of intrahepatic cholestasis of pregnancy, serum TSH, TPOAb, IL-18 and TNF- alpha levels, and maternal and child outcomes. Methods One hundred and twenty-six cases of intrahepatic cholestasis of pregnancy treated in our hospital were equally and randomly divided into the study group and control group. The control group was treated with ursodeoxycholic acid tablets and ademetionine1,4-butanedisulfonate, while the study group was additionally given bile stasis, a traditional Chinese medicine. Another 100 healthy pregnant women served as the healthy group. The serum levels of TSH, TPOAb, IL-18 and TNF- alpha of the three groups were tested to observe the curative effect in the first two groups of patients and pregnancy outcomes. Results The serum TSH, TPOAb, IL-18 and TNF- alpha levels in the two groups of patients were not significantly different(P>0.05), but were higher than those in the healthy group(P<0.05). After treatment, serum TSH, TPOAb, IL-18 and TNF- alpha levels of the two groups of patients were significantly improved, especially in the study group(P<0.05). The total effective rate in the study group was significantly higher than that in the control group(P<0.05), and the incidence of adverse pregnancy outcomes in the study group was significantly lower than that in the control group(P<0.05). Conclusion The treatment of intrahepatic cholestasis of pregnancy with traditional Chinese medicine and Western medicine can effectively improve the serum levels of TSH, TPOAb, IL-18 and TNF- alpha, improve the curative effect, and help ensure good maternal and child outcomes.
Keywords：intrahepatic cholestasis of pregnancyserum thyroid stimulating hormonethyroid peroxidase antibodyinterleukin -18serum tumor necrosis factor-α
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 65-68 )