Expression of matrix metalloproteinases in oral squamous cell carcinoma and its effects on biological behavior
TAN Zhanmin
XU Zhipeng
CHEN Xiaolong
ZHANG Jie
DONG Yufen
Abstract：Objective To investigate the expression of matrix metalloproteinases(MMPs) in oral squamous cell carcinoma and their biological behavior. Methods The expressions of MMP-2 and MMP-9 in oral and normal oral tissues were detected by immunohistochemistry. The association between high expressions of MMP-2 and MMP-9 and clinical cervical lymph node metastasis was analyzed. The effect of MMP-2 and MMP-9 expressions on the migration of oral squamous cell carcinoma cells was examined by scratch test. The effect of MMP-2 and MMP-9 expressions on the invasive ability of oral squamous cell carcinoma cells was detected by Transwell assay. Results Compared with normal oral tissue, the expressions of MMP-2 and MMP-9 in oral squamous cell carcinoma were significantly up-regulated. The high expressions of MMP-2 and MMP-9 were positively correlated with cervical lymph node metastasis in clinical patients. Inhibition of MMP 2 and MMP-9 expressions can inhibit the migration and invasion of oral squamous cell carcinoma cells. Conclusions The expressions of MMP-2 and MMP-9 in oral cancer are significantly increased. Inhibition of MMP-2 and MMP-9 expressions can regulate the biological behavior of oral squamous cell carcinoma.
Keywords：matrix metalloproteinasesMMP-2MMP-9oral squamous cell carcinomaaggressive behavior
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 61-64 )