Diagnostic value of retinal-binding protein, serum cystatin C in chronic kidney disease
MA Hongyu
DONG Lei
QUAN Shouzhen
WANG Ting
LUO Dan
Abstract：Objective To explore the diagnostic value of cystatin C(CysC), retinal-binding protein and other indi-cators of kidney function in different stages of chronic kidney disease(CKD). Methods A total of 141 patients with CKD were collected as the case group while another 23 cases of normal adults served as the control group. The levels of serum Cys C, β2-MG, RBP, URBP, UACR and other indicators of kidney function were detected. The sensitivity and specificity of each indicator in the early pathological changes were evaluated with ROC curves. Results The levels of serum Cys C and β2-MG were significantly higher from stage 2 of CKD than those in the control group(P<0.05). The level of URBP was significantly higher than that in the control group from stage 3a of CKD(P<0.05). RBP, Cys C, β2-MG and UACR had a positive correlation with Cr as well as Urea, but a negative correlation with eGFR. The ROC curves showed that UACR, URBP, Cys C and β2-MG had higher accuracy in the early diagnosis of CKD. Conclusion Kidney damage can be diag-nosed early by detecting UACR, URBP, serum CysC and β2-MG, and simultaneous detection of them can be of great clini-cal significance for early diagnosis of CKD.
Keywords：retinal-binding proteincystatin Cβ2-microglobulinchronic kidney diseaseglomendar filtration rate
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 45-47,51 )