Diagnostic value of FibroScan detection in primary liver cancer

WEI Hua; BIAN Lili

Abstract：Objective To study the diagnostic value of liver hardness in primary liver cancer detected using FibroScan.Methods 285 cases of hepatic sclerosis (LC) and another 285 cases of primary liver cancer (HCC) admitted to our hospital between December 2014 and January 2016 were selected as subjects. These patients were divided into primary liver cancer group (HCC group) and cirrhosis group (LC group) according to the types of diseases. FibroScan examination results and serum markers were compared between the two groups, and the diagnostic value of FibroScan for primary liver cancer was analyzed.Results The age of patients, ALP, GGT, APRI, TBIL, ALB, PAT, LS and AFP of the two groups were significantly different, and the difference was statistically significant (P<0.05). The multivariate logistic regression analysis showed that age, GGT, APRI, LS and AFP were independent risk factors for HCC, and the difference was statistically significant (P<0.001). The mean value of LS in LC group was significantly lower than that in HCC group (P<0.05). The standard error of LS was 0.008, the 95％CI was 0.876-0.914, and its accuracy of diagnosis was significantly higher than that of TBIL, ALP, GGT, AFP, APRI (P<0.05). 16.89 kPa was the optimal threshold for the diagnosis of HCC, and the sensitivity and specificity were 81.21％ and 80.96％, respectively. The LS value was 23.69 kPa, the sensitivity was 66.01％ and the specificity was 90.11％ when the specificity was set to be>90％.Conclusion FibroScan has a high diagnosis rate of primary liver cancer by detecting the liver hardness of patients, which is worthy of clinical application.