Effect of GBE on expressions of LOX-1 and NF-κB in aortas of hyperlipidemic rats exposed to repeated positive acceleration
YANG Zhihui
YUAN Hailong
GE Hua
HUANG Jinghui
FU Zhaojun
ZHANG Qingjun
ZHANG Fucheng
WANG Jianchang
Abstract：Objective To investigate the effect of Ginkgo biloba extract (GBE) on the expression of LOX-1 and NF-κB in aortas of high-fat diet-induced hyperlipidemic rats exposed to repeated positive acceleration.Methods Fifty male Sprague-Dawley rats were randomly allocated to five groups, including a control group, a high lipid with repeated positive acceleration stress group, a low dosage group of GBE, a middle dosage group of GBE, and a high dosage group of GBE. The rats of control group were fed with common feed and those of other groups were administered with high lipid feed and exposed to repeated positive acceleration. After eight weeks of intragastric administration with GBE, the serum was separated, and thoracic aortas were kept. The following indicators were observed: lipid metabolism indicators, oxidative stress indicators and inflammation reaction indicators, and the protein expressions of LOX-1 and NF-κB.Results GBE reduced ox-LDL, down-regulated LOX-1 expression, inhibited NF-κB activation and decreased the generation of proinflammatory factors.Conclusion GBE can protect against the inflammation of aortas of high-fat diet-induced hyperlipidemic rats exposed to repeated positive acceleration by down-regulating LOX-1 expression and inhibiting NF-κB activation.
Keywords：Ginkgo biloba extractpositive accelerationhyperlipidemiaLOX-1NF-κB
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 361-365 )