Safety of mifepristone and hysteroscopy combined with laparoscopy in treatment of uterine scar pregnancy after cesarean section

LI Jing; ZHANG Chunlian; FANG Caiyun

Abstract：Objective To study the safety of mifepristone and hysteroscopy combined with laparoscopy in the treatment of uterine scar pregnancy after cesarean section, and to provide data for clinical treatment.Methods Using random number table method, 137 subjects were selected and divided into two groups: the observation group (69 cases) treated with mifepristone and hysteroscopy combined with laparoscopy, and the control group (68 cases) treated with hysteroscopy combined with laparoscopy. After operation, the success rate, duration of surgery, safety, intraoperative blood loss, duration of vaginal bleeding, bloodβ-HCG recovery time, menstrual recovery time and other data were compared between the two groups and statistically analyzed.Results The success rate was 98.6% in the observation group and 88.2% in the control group. The therapeutic effect in the observation group was significantly better than in the control group (P<0.05). The incidence of complications was 18.8% in the observation group and 26.5% in the control group (P<0.05). In the observation group, the duration of surgery, intraoperative bleeding volume, duration of vaginal bleeding, hospital stay were respectively (22.6±4.5) min, (32.5±5.6) ml, (18.2±5.3) d and (12.5±2.6) d, which were significantly better than in the control group (P<0.05). In the observation group, bloodβ-HCG and menstrual recovery time were (32.8±6.3) d and (28.6±4.8) d respectively, which were significantly better than in the control group (P<0.05).Conclusion Mifepristone, hysteroscopy combined with laparoscopy technique can ensure a high success rate for the treatment of uterine scar pregnancy after cesarean section. This approach is safe, effective without affecting the menstrual recovery.