Changes of gastric motility in children with bronchopneumonia and its mechanism

WU Yuping; XU Hua

Abstract：Objective To observe the changes of gastric electrical parameters and gastrointestinal hormones in children with bronchopneumonia and to explore the possible mechanism of gastric motility.Methods Forty-eighty children with bronchopneumonia and forty-five healthy children were recruited to detect gastric electrical parameters and the blood serum contents of motilin(MLT) and vasoactive intestinal peptide (VIP). The difference of gastric electrical parameters and gastrointestinal hormones between the two groups was analyzed. The correlations between gastric electrical parameters and gastrointestinal hormones were also evaluated.Results ①Compared with the normal group, values of preprandial average amplitude (VPP) and preprandial dominant frequency (DF) in pneumonia group increased significantly (allP<0.01), while postprandial / pretprandial power ratio (PR) was reduced (P<0.05), but values of postprandial VPP, postprandial DF and pre-and postprandial percentage of normal slow wave (PNSW) showed no obvious change (P>0.05).② Compared with the normal group, the VIP level of pneumonia group increased significantly (P<0.05), while MLT level changed little (all P>0.05).③Correlation analysis showed that MLT level was negatively correlated with preprandial DF (P<0.01), but positively correlated with postprandial PNSW (P<0.05) and postprandial DF (P<0.01). Fasting serum VIP level was positively correlated with preprandial VPP (P<0.01) and preprandial PNSW (P<0.05), but negatively correlated with postprandial VPP (P<0.01), postprandial DF (P<0.01), postprandial PNSW (P<0.05) and PR (P<0.01).Conclusion There is abnormal gastric electrical activity and gastrointestinal hormone secretion disorders in children with pneumonia. The main cause of abnormal gastric motility is relatively insufficient postprandial gastric motility and abnormal gastric emptying, which is closely related to the increase of serum VIP.